Littlefoot and his friends (along with Ash, SpongeBob, Stan, and their friends) take a time-travel vacation to San Francisco and reunite with Charlie and his recently-deceased best friend Itchy as they meet a female dog named Sasha and her young owner David and find Gabriel's horn to return it to heaven before Red, Carface, Plankton, Pete, The Horned King, Creeper, Oogie Boogie, Ichy, Dil, The Machine, The Fratellis (Ma Fratelli, Francis Fratelli, and Jake Fratelli), and Team Rocket (Jessie, James, and Meowth) find it.
- Ash Ketchum, Pikachu, Misty, Brock, Togepi, SpongeBob SquarePants,Patrick Star, Squidward Tentacles, Sandy Cheeks, Eugene Krabs, Stan Marsh, Kyle Broflovski, Eric Cartman, Kenny McCormick, Scooby-Doo,Shaggy Rogers, Fred Jones, Daphne Blake, Velma Dinkley, Mickey Mouse, Donald Duck, Goofy, Celebi,Taran, Princess Eilonwy, Fflewddur Fflam, Gurgi, Orddu, Orgoch, and Orwen, The Flying Dutchman, Jesse Greenwood, Willy the Whale (cameo), Elvis, Randolph Johnson, Nadine, Mo (cameo), The Goonies (Mikey Walsh, Brand Walsh, Mouth Devereaux, Data Wang, Chunk Cohen, Andy Carmichael, Stef Steinbrenner, and Sloth Fratelli), Slimer, Stay Puft, Jack Skellington, Rex, Woog, Elsa, Dweeb Walter The Penguin Mary May Andre Steve Harry Withney Thalice Toni Paula, and Billy Baker Ttark The Masters of Evil, , Oogie Boogie, Sheldon J. Plankton, Pete, The Horned King, Creeper, Ichy and Dil, The Machine, The Fratellis (Ma Fratelli, Francis Fratelli, and Jake Fratelli), and Team Rocket (Jessie, James, and Meowth) guest star in this film.
- In this film, Elvis, Nadine, Jack Skellington, Rex, Woog, Elsa, and Dweeb meet Charlie and Itchy for the first time.
- This film marks the first time Elvis and Nadine face The Machine, who is Jesse's old enemy from the animated Free Willy TV series, and The Horned King. This also marks the first time Charlie and Itchy face Oogie Boogie and The Horned King and the first time Rex, Woog, Elsa, and Dweeb face The Horned King.
- Willy and Mo will make a few cameos in this film.
- Like SuperKitaroShinX's film Pooh's Adventures of All Dogs Go to Heaven 2, this is an NTSC film with NTSC bits from The Land Before Time movies and the Pokémon movies, The SpongeBob SquarePants Movie,South Park: Bigger, Longer & Uncut, the Scooby-Doo movies, Mickey, Donald, Goofy: The Three Musketeers, A Goofy Movie, An Extremely Goofy Movie, Mickey's House of Villains, The Black Cauldron,Free Willy 1-3, The Goonies, The Nightmare Before Christmas, Andre 1994 and We're Back! A Dinosaur's Story.